Thyroglobulin domain

Thyroglobulin type-1 repeat

Thyroglobulin type-1 domain

Identifiers

Symbol

Thyroglobulin_1

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe
PDBsum	structure summary

Thyroglobulin type-1 repeat is an evolutionary conserved protein domain. Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.

Human proteins containing this domain

CD74; IGFBP-4; IGFBP1; IGFBP2; IGFBP3; IGFBP4; IGFBP5; IGFBP6; NID1; NID2; SMOC1; SMOC2; SPOCK1; SPOCK2; SPOCK3; TACSTD1; TACSTD2; TG;

References

Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S. Guncar G, Pungercic G, Klemencic I, Turk V, Turk D; EMBO J 1999;18:793-803.PubMed
Characterization of the type-1 repeat from thyroglobulin, a cysteine- rich module found in proteins from different families. Molina F, Bouanani M, Pau B, Granier C; Eur J Biochem 1996;240:125-133. PubMed

This article incorporates text from the public domain Pfam and InterPro IPR000519